Increased central aortic stiffness and left ventricular mass in normotensive young subjects after successful coarctation repair
Identifieur interne : 008C59 ( Main/Exploration ); précédent : 008C58; suivant : 008C60Increased central aortic stiffness and left ventricular mass in normotensive young subjects after successful coarctation repair
Auteurs : Phalla Ou [France] ; David S. Celermajer [Australie] ; Odile Jolivet [France] ; Fanny Buyens [France] ; Alain Herment [France] ; Daniel Sidi [France] ; Damien Bonnet [France] ; Elie Mousseaux [France]Source :
- The American heart journal [ 0002-8703 ] ; 2008.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Background Hypertension occurs in 20% to 40% of survivors of anatomically successful repair of aortic coarctation (CoA). The aim of the present study was to examine the role of central aortic function in this setting. Methods Forty normotensive asymptomatic subjects with successful CoA repair (age 12 ± 8 years) and 20 age- and sex-matched control subjects underwent detailed magnetic resonance imaging investigation of the thoracic aorta and left ventricle. Aortic distensibility, compliance, and stiffness β index were calculated in the central (precoarctation) and descending (postcoarctation) aorta. Aortic pulse wave velocity was measured and left ventricular mass was calculated. Results Compared to control subjects, CoA subjects had markedly decreased central aortic distensibility (2.8 ±0.7vs4.2 ± 0.5 mm Hg-1 10-3, P<.001) and compliance (1.7 ± 0.3 vs 2.5 ± 0.6 mm2 mm Hg-1, P<.001) and increased stiffness β index (5.2 ± 1 vs 2.5 ± 0.6, P <.001). Pulse wave velocity was also significantly increased in the CoA subjects (4.7 ± 1.3 vs 3.3 ± 0.6 m/sec, P<.001). Left ventricular mass index was higher in the CoA subjects (84 ± 11 vs 73 ± 10 g/m2, P =.01) and correlated significantly with aortic stiffness β index (r2 = 0.8, P <.0001). By contrast, descending aortic characteristics were similar in the CoA and control subjects. Conclusion Central aortic stiffness is markedly increased and associated with increased left ventricular mass in normotensive young subjects after successful early repair of CoA.
Affiliations:
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<author><name sortKey="Buyens, Fanny" sort="Buyens, Fanny" uniqKey="Buyens F" first="Fanny" last="Buyens">Fanny Buyens</name>
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<country>France</country>
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<region type="old region">Île-de-France</region>
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</placeName>
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<author><name sortKey="Herment, Alain" sort="Herment, Alain" uniqKey="Herment A" first="Alain" last="Herment">Alain Herment</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>INSERM UMR_S678, CHU la Pitié-Salpétrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
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<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
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<author><name sortKey="Sidi, Daniel" sort="Sidi, Daniel" uniqKey="Sidi D" first="Daniel" last="Sidi">Daniel Sidi</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Pediatric Cardiology, Hôpital Necker-Enfants Malades, University Rene Descartes-Paris 5</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bonnet, Damien" sort="Bonnet, Damien" uniqKey="Bonnet D" first="Damien" last="Bonnet">Damien Bonnet</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Pediatric Cardiology, Hôpital Necker-Enfants Malades, University Rene Descartes-Paris 5</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mousseaux, Elie" sort="Mousseaux, Elie" uniqKey="Mousseaux E" first="Elie" last="Mousseaux">Elie Mousseaux</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>INSERM UMR_S678, CHU la Pitié-Salpétrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Cardiovascular Radiology, Hôpital Européen Georges Pompidou, University Rene Descartes-Paris 5</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">The American heart journal</title>
<title level="j" type="abbreviated">Am. heart j.</title>
<idno type="ISSN">0002-8703</idno>
<imprint><date when="2008">2008</date>
</imprint>
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</sourceDesc>
<seriesStmt><title level="j" type="main">The American heart journal</title>
<title level="j" type="abbreviated">Am. heart j.</title>
<idno type="ISSN">0002-8703</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aorta</term>
<term>Cardiology</term>
<term>Circulatory system</term>
<term>Corrective surgery</term>
<term>Human</term>
<term>Left ventricle</term>
<term>Mass</term>
<term>Phlebology</term>
<term>Repair</term>
<term>Stiffness</term>
<term>Treatment</term>
<term>Tumor</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Tumeur</term>
<term>Aorte</term>
<term>Rigidité</term>
<term>Ventricule gauche</term>
<term>Masse</term>
<term>Homme</term>
<term>Réparation</term>
<term>Traitement</term>
<term>Chirurgie correctrice</term>
<term>Appareil circulatoire</term>
<term>Cardiologie</term>
<term>Phlébologie</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background Hypertension occurs in 20% to 40% of survivors of anatomically successful repair of aortic coarctation (CoA). The aim of the present study was to examine the role of central aortic function in this setting. Methods Forty normotensive asymptomatic subjects with successful CoA repair (age 12 ± 8 years) and 20 age- and sex-matched control subjects underwent detailed magnetic resonance imaging investigation of the thoracic aorta and left ventricle. Aortic distensibility, compliance, and stiffness β index were calculated in the central (precoarctation) and descending (postcoarctation) aorta. Aortic pulse wave velocity was measured and left ventricular mass was calculated. Results Compared to control subjects, CoA subjects had markedly decreased central aortic distensibility (2.8 ±0.7vs4.2 ± 0.5 mm Hg<sup>-1</sup>
10<sup>-3</sup>
, P<.001) and compliance (1.7 ± 0.3 vs 2.5 ± 0.6 mm<sup>2</sup>
mm Hg<sup>-1</sup>
, P<.001) and increased stiffness β index (5.2 ± 1 vs 2.5 ± 0.6, P <.001). Pulse wave velocity was also significantly increased in the CoA subjects (4.7 ± 1.3 vs 3.3 ± 0.6 m/sec, P<.001). Left ventricular mass index was higher in the CoA subjects (84 ± 11 vs 73 ± 10 g/m<sup>2</sup>
, P =.01) and correlated significantly with aortic stiffness β index (r2 = 0.8, P <.0001). By contrast, descending aortic characteristics were similar in the CoA and control subjects. Conclusion Central aortic stiffness is markedly increased and associated with increased left ventricular mass in normotensive young subjects after successful early repair of CoA.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
</country>
<region><li>Nouvelle-Galles du Sud</li>
<li>Île-de-France</li>
</region>
<settlement><li>Paris</li>
<li>Sydney</li>
</settlement>
<orgName><li>Université de Sydney</li>
</orgName>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Ou, Phalla" sort="Ou, Phalla" uniqKey="Ou P" first="Phalla" last="Ou">Phalla Ou</name>
</region>
<name sortKey="Bonnet, Damien" sort="Bonnet, Damien" uniqKey="Bonnet D" first="Damien" last="Bonnet">Damien Bonnet</name>
<name sortKey="Buyens, Fanny" sort="Buyens, Fanny" uniqKey="Buyens F" first="Fanny" last="Buyens">Fanny Buyens</name>
<name sortKey="Herment, Alain" sort="Herment, Alain" uniqKey="Herment A" first="Alain" last="Herment">Alain Herment</name>
<name sortKey="Jolivet, Odile" sort="Jolivet, Odile" uniqKey="Jolivet O" first="Odile" last="Jolivet">Odile Jolivet</name>
<name sortKey="Mousseaux, Elie" sort="Mousseaux, Elie" uniqKey="Mousseaux E" first="Elie" last="Mousseaux">Elie Mousseaux</name>
<name sortKey="Mousseaux, Elie" sort="Mousseaux, Elie" uniqKey="Mousseaux E" first="Elie" last="Mousseaux">Elie Mousseaux</name>
<name sortKey="Ou, Phalla" sort="Ou, Phalla" uniqKey="Ou P" first="Phalla" last="Ou">Phalla Ou</name>
<name sortKey="Sidi, Daniel" sort="Sidi, Daniel" uniqKey="Sidi D" first="Daniel" last="Sidi">Daniel Sidi</name>
</country>
<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Celermajer, David S" sort="Celermajer, David S" uniqKey="Celermajer D" first="David S." last="Celermajer">David S. Celermajer</name>
</region>
</country>
</tree>
</affiliations>
</record>
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